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Hans Christian Gram: Biologist who supports bacterial research

The inventor of Gram staining technology, Hans Christian Gram, was a pioneering biologist who devised a classification system, which investigated 30,000 officially named bacteria. He is the latest Google Graffiti theme created to honor the birth date of September 13, 1853. Gram invented this technique in Berlin in the early 1880s in collaboration with a German pathologist and microbiologist Carl Friedlander. It is still known as one of the most important staining techniques used in microbiology to identify bacteria under a microscope.

New Scientist Hans Christian Gram

Gram first dropped the reagent, a substance that causes a chemical reaction in lung tissue samples. He has now discovered a difference in the coloration of bacteria known as Streptococcus pneumoniae and Klebsiella pneumoniae. The difference observed in grams is a result of the bacterial cell wall composition. Some bacteria have a cell wall composed of peptidoglycan, sugar and amino acid polymers. This “gram-positive” bacterial cell maintains the staining color (usually a complex of crystal violet and iodine, or methylene blue) and appears purple or brown on the microscope. Others that do not contain peptidoglycan are not stained and are called gram negative and appear red.

Gram first dropped the reagent, a substance that causes a chemical reaction in lung tissue samples. He has now discovered a difference in the coloration of bacteria known as Streptococcus pneumoniae and Klebsiella pneumoniae. The difference observed in grams is a result of the bacterial cell wall composition. Some bacteria have a cell wall composed of peptidoglycan, sugar and amino acid polymers. This “gram-positive” bacterial cell maintains the staining color (usually a complex of crystal violet and iodine, or methylene blue) and appears purple or brown on the microscope. Others that do not contain peptidoglycan are not stained and are called gram negative and appear red.



Harvard Medical School Associate Professor Pierce Gardner wrote in 1974 about Gram staining and its interpretation. “Gram stained stain is a feeling that should be considered part of the physical part is the examination of patients with acute bacterial infections and belongs to the repertoire of all doctors who provide primary care to acute patients “

 Hans Christian Gram

More recently, it was used to identify new antibiotics to combat Gram stain antibiotic resistance. Teixobactin, one of two new antibiotics released in the pharmaceutical market in 2015, confirmed by applying a new variant in a proven way to sort out bacterial soil that has evolved to kill competitors.

A team from Northwestern University in Boston, Massachusetts has screened 50,000 soil bacteria against antibiotics that killed hospital-infected MRSA and insects such as bacteria that cause multi-drug resistant tuberculosis .

The staining technique was important because the screen identified teixobactin, which seems to act on the “gram-positive” group of bacteria by targeting cell wall lipids along with other molecules . When used correctly, the researchers behind the discovery of teixobactin can be a viable treatment option for bacterial disease for at least 30 years and can be safe from resistance threats.

Differentiating bacteria by Gram-positive or voice is fundamental to most bacterial identification systems, but researchers say Gram staining is prone to this error and is “not well controlled and lacks standardization.” Insisted. 1884


He pointed out, “I know that this method is still flawed and incomplete, but I announced this method.” “But I hope it helps other researchers.”

“I know that this method is still flawed and incomplete, but I announced this method.” “But I hope it helps other researchers.”

Hans Christian Gram

Due to problems with the Gram method, other tests were searched, and several options appeared in the literature claiming improvement. Nevertheless, Gram staining is one of the most commonly performed tests in clinical microbiology laboratories and is a fundamental technique for treating bacterial lives and saving lives.

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